Anesthesia Pharmacology: Serotonin-related Practice Questions

Serotonin is formed from:
1. tyrosine
2. L-tryptophan
3. glutamine
4. glutamic acid
5. dopamine
Most of the serotonin in the body its found in:
1. mast cells
2. cardiac cells
3. enterochromaffin cells
4. liver cells
5. the lungs
The neurotransmitter serotonin may be involved in:
1. carcinoid syndrome
2. depression
3. anxiety
4. migraine headaches
5. all of the above
Serotonin is metabolized primarily by:
1. catechol-O-methyltransferase
2. monoamine oxidase
3. deaminases
4. sulfotransferases
5. excreted in the urine mainly unchanged
Coupling mechanism for most serotonin receptors:
1. ion channels
2. G proteins
Serotonin effects on the gastrointestinal tract:
1. increased tone; increased peristalsis
2. decreased tone; decreased peristalsis
Over production and release of serotonin in carcinoid tumor most likely will cause of this effect on the gastrointestinal tract:
1. constipation
2. diarrhea
Bezold-Jarisch reflex (chemoreceptor reflex) involves:
1. tachycardia blocked by phentolamine (Regitine)
2. bradycardia blocked by atropine
3. activation of 5 HT1 receptors
4. hypertension
5. none of the above
Serotonin receptor type most likely involved in mediating the vomiting reflex:
1. 5-HT1
2. 5-HT2
3. 5-HT3
Particularly in patients with carcinoid syndrome, serotonin elevation may cause this effect on bronchiolar smooth muscle:
1. bronchodilation
2. bronchoconstriction
3. none of the above; serotonin in this case will have limited affects on bronchiolar smooth muscle