Anesthesia Pharmacology: Serotonin-related Drug Practice Questions

This antidepressant is classified as a serotonin-selective re-uptake inhibitor:
1. fenfluramine (Pondimin)
2. ondansetron (Zofran)
3. fluoxetine (Prozac)
4. buspirone (BuSpar)
5. ketanserin
Serotonin receptor antagonist; prominent antimuscarinic action; and used to treat symptoms of carcinoid tumor
1. cimetidine (Tagamet)
2. ondansetron (Zofran)
3. cyproheptadine (Periactin)
4. sumatriptan (Imitrex)
5. none of the above
Primary serotonergic effect on human smooth muscle (except for skeletal muscle vasculature and cardiac vessels)
1. relaxation
2. contraction
Serotonin flush is most likely due to:
1. increased blood pressure
2. venoconstriction
3. vasodilation
4. increased myocardial contractility
5. increased oxygenation of the blood
Drug(s) that most likely would prevent Bezold-Jarisch reflex (chemoreceptor reflex):
1. atropine
2. ondansetron (Zofran)
3. both
4. neither
Location of most stored serotonin:
1. mast cells
2. muscle cells
3. lung
4. enterochromaffin cells of the gastrointestinal tract
5. raphe nuclei
Primary amino acid precursor in serotonin synthesis:
1. tyrosine
2. tryptophan
3. glycine
4. phenylalanine
5. histidine
Antipsychotic drug: a partially selective 5 HT (serotonin) antagonist; is associated with the risk of agranulocytosis
1. buspirone (BuSpar)
2. ketanserin
3. clozapine (Clozaril)
4. methysergide (Sansert)
5. none of the above
This drug, will usually relieve symptoms of migraine, but is contraindicated in patients with coronary vascular disease.
1. cyproheptadine (Periactin)
2. sumatriptan (Imitrex)
3. fenfluramine (Pondimin)
4. ondansetron (Zofran)
5. A & B