Anesthesia Pharmacology Chapter 24: Vasoactive Peptide Practice Questions

Concerning the intrarenal baroreceptor receptor pathway in regulation of renin:
1. Increases or decreases in preglomerular vessel blood pressure can change renin release..
2. Changes in renal perfusion pressure influence renin release.
3. Both
4. Neither
Concerning the ß1 adrenergic receptor and renin release:
1. Postganglionic sympathetic nerves releasing norepinephrine activates juxtaglomerular ß1 receptors.
2. Administration of ß receptor antagonists (blockers) increases renin secretion and plasma renin activity
3. Both
4. Neither
Angiotensinogen is the renin substrate.
1. True
2. False
Effect(s) associated with angiotensin 1 receptor activation:
1. Vasoconstriction
2. Vascular smooth muscle cellular inflammation
3. Cardiac hypertrophy
4. Reduced fibrosis
5. A & B
6. A & C
7. A, B & C
8. A, B, C, & D
Effect(s) associated with angiotensin 2 receptor activation:
1. Vasodilation
2. Anti-proliferation
3. Diminished oxidative stress
4. Antifibrotic activity
5. Reduced inflammation
6. A, B & C
7. A, B & D
8. A, B, C, D & E
Example of a selective ACE (angiotensin-converting enzyme) inhibitor:
1. Losartan
2. Aliskiren
3. Enalapril
4. Candesartan Cilexetil
Which one(s) of the following renin-angiotensin system inhibitors is/are prodrugs?
1. Eprosartan
2. Candesartan Cilexetil
3. Enalapril
4. A & B
5. B & C
6. A & C
7. A, B & C
Which one(s) of the following concerning angiotensin II receptors is/are correct?
1. Angiotensin II receptors exhibited limited distribution, confined mainly to the CNS.
2. Angiotensin II receptors are localized on plasma membranes and are categorized is G protein-coupled system
3. Both
4. Neither
This type of angiotensin II receptor subtype when activated resultant vasodilation.
1. AT1
2. AT2
Most action so far described of angiotensin II occur as a result of AT1 receptor activation.
1. True
2. False