Anesthesia Pharmacology Chapter 24: Vasoactive Peptide Practice Questions

Which one(s) of the following statements is/are correct concerning kinins?
1. Kinins are effective vasoconstrictor peptides
2. The synthesis of kinins is catalyzed by kallikreins.
3. Kallikreins act on substrates called kininogens.
4. A & B
5. B & C
6. A & C
7. A, B & C
Kallikreins are categorized as this type of enzyme
1. Carboxypeptidase
2. Transaminase
3. Serine protease
Kallikreins are located in plasma and in some organs.
1. True
2. False
Kallikreins are secreted as zymogens and subsequently activated (proteolytic cleavage).
1. True
2. False
Plasma prekallikrein requires activated blood coagulation factor XII (FXIIa).
1. True
2. False
Kinin(s) considered major prominent in humans.
1. Bradykinin
2. Lys-bradykinin
3. Both
4. Neither
Released from high molecular weight kininogen through the action of plasma kallikrein:
1. Kallidin (Lys-bradykinin)
2. Bradykinin
Low-molecular-weight kininogen acted on by tissue kallikrein is the kallidin precursor.
1. True
2. False
Prominent kinin in plasma:
1. Lys-bradykinin
2. Bradykinin
3. Both
4. Neither
Kinins are characterized by relatively slow metabolism.
1. True
2. False