Medical Pharmacology: Antibacterial Drug Practice Questions
Sulfonamide
Sulfadiazine (Lantrisul and others)
Click on the correct answer.
Urinary tract infections:
Common painful illness
Usually responsive to contemporary antibiotic treatment
Nitrofurantoin (1950s) has been identified as the
first tolerable as well as effective drug for treatment of UTI.
A & B
B & C
A & C
A, B & C
Acute cystitis: most common UTI clinical manifestation.
True
False
Urinary tract infection include/includes:
Asymptomatic bacturia (ASB)
Cystitis
Prostatitis
Pyelonephritis
A & C
D only
A, B, C & D
Definitions:
Cystitis: symptomatic bladder infection
Pyelonephritis: symptomatic renal infection
Both
Neither
Pyelonephritis is defined as an infection involving the renal parenchyma.
True
False
"Complicated urinary tract infection": symptoms indicative of an infection beyond the bladder, including symptoms of systemic illness e.g. fever.
True
False
Catheter-associated bacturia (CAUTI) may be either symptomatic or asymptomatic.
True
False
With the exception of infant or older adults, UTI is more likely to occur in females compared to males.
True
False
Beyond the age of 50, prostatic hypertrophy (BPH) results in a change in the incidence of UTI. In this case, because of obstruction, UTI is almost as likely to occur in men as in women.
True
False
Factors that make women predispose to cystitis also predispose women to increased pyelonephritis risk.
True
False
Concerning uropathogens which cause urinary tract infections:
Uropathogens resulting in UTI vary by clinical syndrome
Uropathogens resulting in UTI are usually enteric gram-negative rods which have migrated to the urinary tract.
Both
Neither
Pathogen/pathogens involved in acute, uncomplicated cystitis in the US:
E. coli
(75-90% of isolates)
Staphylococcus saprophyticus (5-15%)
Both
Neither
Less common organisms/organisms associated with acute uncomplicated cystitis (US):
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Source Material:
MacDougall C Chapter
56: Sulfonamides, Trimethoprim-Sulfamethoxazole,
Quinolones and Agents for Urinary Tract Infections in Goodman & Gilman's: The Pharmcological
Basis of Therapeutics, 13e, (Brunto LL Hilal-Dandan R Knollmann
BC, eds) McGraw-Hill Education, 2018.
Gruenberg K
Guglielmo BJ e1-13: Sulfonamides & Antifolate Medications in Current Medical Diagnosis & Treatment (Papadakis
MA McPhee SJ Rabow MW McQuaid KR, eds) 61e McGraw Hill 2022.
Beauduy; CE Winston
LG Chapter 46: Sulfonamides, Trimethoprim, & Quinolones
in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah
TW, Associate editor) 15e McGraw Hill 2021.
Drugs (Access
Medicine)
Gupta K Trautner BW
Chapter 135: Urinary Tract Infections, Pyelonephritis and
Prostatitis in Harrison's Principles of Internal Medicine 21st
Editions, Loscalzo J Fauci A Kasper D Hauser S Longo D Jameson
JL,eds) McGraw Hill LLC, 2022.
