Medical Pharmacology Chapter 35: Antibacterial Drug Practice Questions

Sulfadoxine pharmacology:
1. Unusually short half-life
2. In combination with pyrimethamine, sulfadoxine can be used to prevent and treat malaria
3. Both
4. Neither
Uses sulfadoxine in combination with pyrimethamine may induce:
1. Occasional fatal drug reactions, including Stevens-Johnson syndrome.
2. Emergence of resistant malarial strains
3. Both
4. Neither
Sulfacetamide (Ovace Plus and others):
1. Is a derivative of sulfanilamide
2. Appropriate for topical use.
3. Both
4. Neither
Sulfacetamide:
1. High aqueous solubility compared to sulfadiazine
2. Useful in treating ophthalmic infections.
3. Both
4. Neither
Sulfacetamide should not be administered to patients who have exhibited hypersensitivity to sulfonamide-class agents.
1. True
2. False
Silver sulfadiazine:
1. Used topically to decrease likelihood of infections stemming from burns.
2. Probably should not be used in managing an established, deep infection.
3. Both
4. Neither
Silver sulfadiazine is considered the likely agent of choice for the purpose of preventing infections due to burns.
1. True
2. False
Mafenide (Sulfamylon):
1. Topical application
2. Prevents colonization by many gram-negative and gram-positive bacteria in the context of burn treatment.
3. Both
4. Neither
Mafenide (Sulfamylon):
1. Mafenide in his principal metabolite inhibit the enzyme carbonic anhydrase thereby resulting in alkalinization of urine.
2. As a consequence of this effect, metabolic acidosis, with tachypnea and hyperventilation may occur; effects that reduce mafenide clinical utility.
3. Both
4. Neither
Mafenide application over a burn area can result in intense pain as well as induce allergic reactions, both notable adverse effects.
1. True
2. False