Medical Pharmacology Chapter 35: Antibacterial Drug Practice Questions

Pharmacological characteristic/characteristics associated with sulfisoxazole (Truxazole):
1. Rapidly absorbed and excreted sulfonamide
2. Reduced renal toxicity associated with previous, older sulfonamides.
3. Both
4. Neither
Renal excretion of sulfisoxazole following a single dose:
1. 10% per day
2. 40% per day
3. 80% per day
4. 95% per day
Given the extent of renal excretion of sulfisoxazole, urinary drug concentration, much higher than that observed in blood, may be bacteriocidal.
1. True
2. False
Compared to sulfadiazine,
1. Sulfisoxazole is more soluble in the urine.
2. Sulfisoxazole is more likely therefore to produce hematuria or crystalluria.
3. Both
4. Neither
For clinical applications requiring both rapid absorption and excretion sulfisoxazole is likely preferred over other sulfonamides.
1. True
2. False
Sulfamethoxazole (Gantanol) compared to sulfisoxazole (close cogeners):
1. Sulfamethoxazole exhibits reduced enteric absorption rates
2. Sulfamethoxazole exhibits slower renal excretion.
3. Both
4. Neither
Generally sulfonamide doses would likely be reduced in patients exhibiting substantial renal failure.
1. True
2. False
Administration of sulfadiazine (with pyrimethamine) is considered first-line treatment in acute toxoplasmosis.
1. True
2. False
Sulfadiazine pharmacology:
1. Rapid G.I. absorption
2. Renal excretion
3. Both
4. Neither
To decrease the possibility of crystalluria, administration of sulfadiazine should be accompanied by adequate fluid intake (about 1200 ml in adults).
1. True
2. False


Sulfamethoxazole (Gantanol)	Sulfadiazine (Lantrisul and others)