Medical Pharmacology: Antibacterial Drug Practice Questions
Triamterene (Dyrenium
and others)
Hyperkalemia may be associated with
trimethoprim administration Note the structural similarity
between triamterene, a potassium-sparing diuretic and
trimethoprim
Trimethoprim (Primsol)
Click on the correct answer.
Greater susceptibility to trimethoprim-sulfamethoxazole combination therapy:
Penicillin-resistant strains
Streptococcus viridans group
Bacterial resistance to trimethoprim-sulfamethoxazole combination therapy is frequently the result of a plasmid acquisition coding for altered dihydrofolate reductase.
True
False
Pharmacokinetics: trimethoprim-sulfamethoxazole
Trimethoprim half-life equals about 11 hours
Sulfamethoxazole half-life equals about 10 hours
Both
Neither
Concerning treatment of
Pneumocystis jiroveci:
High-dose trimethoprim: effective for treating Pneumocystis jiroveci pneumonia
Combination therapy of trimethoprim and sulfamethoxazole may be useful as prophylaxis of
Pneumocyscis jiroveci infections in HIV and in other immunocomprising conditions.
Both
Neither
Trimethoprim-sulfamethoxazole:
May be helpful as adjunctive treatment to incision and drainage of abscesses due to methicillin-resistance
Staphylococcus aureus infections.
Often more effective compared to standard treatment in bacteremia due to invasive methicillin-resistant
Staphylococcus aureus infections.
Both
Neither
In folate-deficient patients the difference between levels of trimethoprim-sulfamethoxazole toxic to bacteria compared to levels toxic to humans may be relatively small.
True
False
Toxicity/toxicities associated with administration trimethoprim-sulfamethoxazole
to patients who were folate deficient:
Leukopenia
Thrombocytopenia
Both
Neither
Toxicity associated with administration of trimethoprim-sulfamethoxazole to the folate deficient patient includes megaloblastosis.
True
False
In patients with renal disease, administration of trimethoprim-sulfamethoxazole may induce permanent renal dysfunction due to sulfamethoxazole crystalluria.
True
False
Adverse hematological reaction/reactions to administration of trimethoprim-sulfamethoxazole includes/includes:
Anemias
Coagulation dysfunction
Granulocytopenia
Purpura
Sulfhemoglobinemia
Henoch-Schonlein purpura
All of the above adverse reactions may occur
Trimethoprim in the kidney:
Administration of high-dose trimethoprim may induce elevation in serum creatinine since trimethoprim reduces creatinine secretion.
Hyperkalemia may be associated with trimethoprim administration.
Both
Neither
HIV patients may exhibit hypersensitivity responses to trimethoprim-sulfamethoxazole
True
False
Hypersensitivity to trimethoprim-sulfamethoxazole in HIV patients include/includes:
If you wish to return to the Table of Contents
in ENGLISH, press the RETURN button above.
Otherwise, if the text is NOT displayed in
English and you are ready to leave this page,
Press here
to return to the Table of Contents
Source Material:
MacDougall C Chapter
56: Sulfonamides, Trimethoprim-Sulfamethoxazole,
Quinolones and Agents for Urinary Tract Infections in Goodman & Gilman's: The Pharmcological
Basis of Therapeutics, 13e, (Brunto LL Hilal-Dandan R Knollmann
BC, eds) McGraw-Hill Education, 2018.
Gruenberg K
Guglielmo BJ e1-13: Sulfonamides & Antifolate Medications in Current Medical Diagnosis & Treatment (Papadakis
MA McPhee SJ Rabow MW McQuaid KR, eds) 61e McGraw Hill 2022.
Beauduy; CE Winston
LG Chapter 46: Sulfonamides, Trimethoprim, & Quinolones
in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah
TW, Associate editor) 15e McGraw Hill 2021.
Drugs (Access
Medicine)
Gupta K Trautner BW
Chapter 135: Urinary Tract Infections, Pyelonephritis and
Prostatitis in Harrison's Principles of Internal Medicine 21st
Editions, Loscalzo J Fauci A Kasper D Hauser S Longo D Jameson
JL,eds) McGraw Hill LLC, 2022.
