Medical Pharmacology Chapter 35: Antibacterial Drug Practice Questions

Nalidixic acid:
1. First quinolone isolated (by-product of chloroquine)
2. Early availability for urinary tract infection uses
3. Both
4. Neither
Example(s) of fluroquinolones (fluorinated 4-quinolones) of therapeutic significance:
1. Norfloxacin
2. Ciprofloxacin
3. Levofloxacin
4. A & B
5. B & C
6. A & C
7. A, B & C
Many quinolones have been withdrawn from the US market due to a variety of potentially serious or fatal side effects identified during postmarketing surveillance.
1. True
2. False
Fluroquinolone antibiotic which due to accumulation at acidic pH values may be particularly helpful against intracellular infections.
1. Ciprofloxacin
2. Delafloxacin
3. Gemifloxacin
4. Moxifloxacin
IDSA (Infectious Diseases Society of America) presently (2022) recommends against using fluoroquinolones as "medications of choice for the treatment of UTI in women."
1. True
2. False
Fluoroquinolones are usually more potent against gram-negative bacteria compared to gram-positive bacteria.
1. True
2. False
Fluroquinolone pharmacokinetics:
1. Well absorbed, widely distributed
2. Concentrated intracellularly
3. Both
4. Neither
Fluroquinolone pharmacokinetics:fluroquinolone antibiotics are best absorbed following oral administration if administered one hour before 2 hours following a meal.
1. True
2. Falls
The shorter half-life fluoroquinolone:
1. Ciprofloxacin
2. Moxifloxacin
3. Both about the same, 6 hours
Primary route of elimination of moxifloxacin and levofloxacin
1. Renal
2. Extra-renal


Ciprofloxacin (Cipro and others)	Moxifloxacin (Vigamox and others)