Medical Pharmacology: Antibacterial Drug Practice Questions
Delafloxacin (Baxdela
and others)
Gemfloxacin (Factive)
Click on the correct answer.
Notably broad spectrum of activity against gram-negative bacteria (including
Pseudomonas aeruginosa (P. aeruginosa)
Ofloxacin
Ciprofloxacinb
Levofloxacin
A & B
B & C
A & C
A, B & C
Resistance associated with fluroquinolone management of serious pseudomonal infections, these agents are typically combined with antipseudomonal
ß-lactams.
Exhibit gram -positive activity against
Streptococcus pneumoniae (S. pneumoniae) and some strains of MSSA (Meticillin-Sensitive-Staphyloccus aureus).
The above agents except for delafloxacin may be used in treating community-acquired pneumonia.
Both
Neither
Typically, strains of methicillin-resistant Staphylococcus aureus (MRSA) exhibit resistance to the action of fluoroquinolones except for delafloxacin.
True
False
Fluoroquinolones may be effective in treating bacterial prostatitis given fluroquinolone penetration into prostate tissue.
True
False
Gatifloxacin, gemifloxacin, moxifloxacin and delafloxacin:
Set of fluoroquinolones with enhanced antibacterial activity with respect to gram-positive organisms, notably
Staphylococcus pneumoniae and some staphylococci.
Delafloxacin among the above
four drugs exhibits antibacterial activity similar to ciprofloxacin with respect to gram-negative bacteria.
Both
Neither
Gatifloxacin is an example of a fluroquinolone only available as an ophthalmic solution (USA).
True
False
Moxifloxacin, due to a tendency to slightly prolong the myocardial QTc interval, should likely be used cautiously in individuals receiving additional QTc-prolonging agents.
True
False
Examples of adverse effects associated with fluroquinolone administration include/includes:
CNS effects (including seizures)
Peripheral neuropathy
Both
Neither
Examples of adverse effects associated with fluroquinolone administration include/includes:
Tendinopathy involving Achilles tendon rupture notably in older patients and patients also receiving glucocorticoids.
Possibly associated with enhance risk of aortic aneurysm due to fluroquinolone effects on connective tissue.
If you wish to return to the Table of Contents
in ENGLISH, press the RETURN button above.
Otherwise, if the text is NOT displayed in
English and you are ready to leave this page,
Press here
to return to the Table of Contents
Source Material:
MacDougall C Chapter
56: Sulfonamides, Trimethoprim-Sulfamethoxazole,
Quinolones and Agents for Urinary Tract Infections in Goodman & Gilman's: The Pharmcological
Basis of Therapeutics, 13e, (Brunto LL Hilal-Dandan R Knollmann
BC, eds) McGraw-Hill Education, 2018.
Gruenberg K
Guglielmo BJ e1-13: Sulfonamides & Antifolate Medications in Current Medical Diagnosis & Treatment (Papadakis
MA McPhee SJ Rabow MW McQuaid KR, eds) 61e McGraw Hill 2022.
Beauduy; CE Winston
LG Chapter 46: Sulfonamides, Trimethoprim, & Quinolones
in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah
TW, Associate editor) 15e McGraw Hill 2021.
Drugs (Access
Medicine)
Gupta K Trautner BW
Chapter 135: Urinary Tract Infections, Pyelonephritis and
Prostatitis in Harrison's Principles of Internal Medicine 21st
Editions, Loscalzo J Fauci A Kasper D Hauser S Longo D Jameson
JL,eds) McGraw Hill LLC, 2022.
