Medical Pharmacology: Cancer Chemotherapy Drug Practice Questions

Suppressed by alkylating-type cancer chemotherapeutic drugs
1. Humoral immunity
2. Cellular immunity
3. Both
4. Neither
Choose the correct statement(s) concerning immunological effects associated with alkylating-type anticancer drug.
1. Alkylating agents may be used to treat some autoimmune diseases.
2. Typically immunosuppression by alkylating agents are irreversible (at typical doses), given the covalent linkages involved.
3. With long-term treatment, alkylating agents used in cancer chemotherapy may induce Pneumocystis jiroveci or fungal infections.
4. A & B
5. B & C
6. A & C
Alkylating agent-type cancer chemotherapy drugs-contraindications:
1. Known drug hypersensitivity
2. Patients with significant bone marrow depression
3. Both
4. Neither
Cautious use(s) of alkylating agent-type cancer chemotherapy drugs include/includes:
1. Previous exposure to chemotherapy
2. Previous exposure to radiation therapy
3. Thrombocytopenia
4. Suboptimal renal or hepatic function
5. A & B
6. B & C
7. A, B, & C
8. All answers (A-D)
Typical antiemetics are very effective in controlling nausea and vomiting associated with alkylating agent chemotherapy administration.
1. True
2. False
Nausea and vomiting associated with administration of alkylating agent-type anticancer medication is directly proportional to the dose.
1. True
2. False
Onset of nausea subsequent to the administration of alkylating agent-type anticancer drugs:
1. Within a few minutes
2. After a several hour delay
3. Both
4. Neither
Bone marrow toxicity associated with alkylating agent-type anticancer drugs may affect which one(s) of the following cell types?
1. Erythrocytes
2. Platelets
3. Leukocytes
4. A & B
5. B & C
6. A & C
7. A, B & C
This alkylating agent-type anticancer drug is associated with relative sparing of hemopoietic stem cells.
1. Busulfan
2. Cyclophosphamide
3. Both
4. Neither
Hemopoietic depression associated with nitrosoureas (such a carmustine) tends to be delayed:
1. True
2. False