Medical Pharmacology: Cancer Chemotherapy Drug Practice Questions
Click on the correct answer.
Clinical application(s) of alkylating anticancer agents include(s):
Suppression of recipient immune responses prior to allogenic transplantation.
Treatment of certain autoimmune diseases
Both
Neither
This alkylating agent toxicity, hemorrhagic cystitis, is most likely to be found with the use of this/these agents.
Busulfan
Ifosfamide
BCNU
A & B
B & C
A & C
A, B & C
In hemorrhagic cystitis which may cause significant bladder pathology with hemorrhage, a primary causative toxicant is acrolein.
True
False
With high cumulative doses, nitrosourea-type alkylating agents are associated with renal toxicity (dose related) that may be sufficiently severe to cause renal failure and death.
True
False
Which one(s) of the following agents may induce pulmonary fibrosis and interstitial pneumonitis?
Busulfan treatment
Cyclophosphamide
Both
Neither
Alkylating agent effect on reproductive tissue: which one(s) of the following statements is/are correct?
Alkylating agent administration may deplete testicular germ cells (not Sertoli cells) and result in aspermia
Patients achieving remission allowing discontinuation of alkylating agents recover spermatogenic activity (in 2-7 years)
Both
Neither
Acute myeloid leukemia (preceded by a myelodysplastic phase) may develop as a second cancer in some patients treated with:
Chlorambucil
Melphalan
Both
Neither
Which one(s) of the following cancer types have been associated with a delayed leukemogenic effect (a second cancer, acute myeloid leukemia)?
Hodgkin lymphoma
Multiple myeloma
Ovarian carcinoma
All of the above
Perhaps 2/3 of individual surviving childhood cancer may display delay drug adverse effects. Example(s) of such complications include/includes:
Cardiopulmonary deficit
Endocrine dysfunction
Renal impairment
A & B
B & C
A & C
A, B & C
Streptozotocin (streptozocin) is used for treating both pancreatic metastatic islet cell carcinoma and malignant carcinoid tumors.