Medical Pharmacology: Cancer Chemotherapy Drug Practice Questions
Click on the correct answer.
Mechlorethamine (Mustargen) was previously used in clinical practice as part of the combination regimen MOPP (mechlorethamine, vincristine, procarbazine, prednisone) for management of patients with Hodgkin's disease.
True
False
Which one(s) of the following represent principal acute toxicities associated with mechlorethamine administration?
Nausea and vomiting
Myelosuppression
Both
Neither
Which one(s) of the following statements concerning cyclophosphamide is/are correct?
Following oral absorption, cyclophosphamide is activated to a 4-hydroxy intermediate.
Non-physiological antidiuretic hormone secretion has been noted in patients receiving cyclophosphamide. as a result, water intoxication must be considered.
Both
Neither
Role(s) of cyclophosphamide in cancer management:
Cyclophosphamide as monotherapy may be curative in Burkitt's lymphoma.
Cyclophosphamide combined with a taxane and doxorubicin may be appropriate as postsurgical adjuvant treatment for breast carcinoma.
Both
Neither
Ifosfamide, a cyclophosphamide analog, may be used in which one(s) of the following clinical settings?
in relapsed germ cell testicular cancer
In the initial treatment of pediatric as well as adults sarcomas
As part of high-dose chemotherapy with subsequent bone marrow/stem cell rescue.
A & B
B & C
A, B & C
Melphalan is mainly used in treating multiple myeloma.
True
False
Chlorambucil:
Historically used nearly exclusively for treating chronic lymphocytic leukemia (CLL)
Presently, CLL is less likely to be treated with chlorambucil and more likely by the combination of cyclophosphamide and fludarabine.
Both
Neither
Bendamustine:
Management of CLL (chronic lymphocytic leukemia)
Management of non-Hodgkin's lymphoma
Both
Neither
Altretamine is considered a palliative agent for cases of recurrent ovarian cancer following cisplatin combination treatment.
