Medical Pharmacology: Cancer Chemotherapy Drug Practice Questions

Which one(s) of the following platinum analogues are used clinically?
1. Carboplatin
2. Oxaliplatin
3. Cisplatin
4. A & C
5. A, B & C
Platinum analog anticancer drugs represent drugs of significant use in systemic therapy for many malignancies and are among the most active class of anticancer drugs.
1. True
2. False
Cisplatin exhibits effectiveness in which one(s) of the following cancer types?
1. Testicular cancer
2. Lung cancer
3. Head and neck cancer
4. A & B
5. B & C
6. A, B & C
Carboplatin appears more effective than cisplatin for addressing germ cell malignancy.
1. True
2. False
Choose the agent considered the more toxic:
1. Cisplatin
2. Carboplatin
Prominent toxicity/toxicities associated with cisplatin administration:
1. Peripheral neuropathy
2. Deafness
3. Nausea and vomiting
4. Renal pathology
5. A & B
6. A & C
7. All of the toxicities (A-D)
Carboplatin:
1. Less neurotoxic compared to cisplatin
2. More myelosuppressive compared to cisplatin
3. Both
4. Neither
In combination with 5-fluorouracil (5-FU), this platinum analog is especially effective in treating colorectal cancer.
1. Carboplatin
2. Oxaliplatin
3. Cisplatin
Cisplatin-based treatment has been shown curative in nonseminomatous testicular cancer.
1. True
2. False
Primary dose limiting toxicity associated with carboplatin:
1. Nephrotoxicity
2. Myelosuppression
3. Hepatotoxicity
4. None of the above