Medical Pharmacology Chapter 33-34: Cancer Chemotherapy
Anti-Metabolite Practice Questions
Click on the correct answer.
Methotrexate:
- Important drug for management of acute lymphoblastic leukemia (MLL) in children.
- Methotrexate is a substantial value in adults with acute myelogenous leukemia (AML).
- Both
- Neither
Route of administration: intrathecal methotrexate-
- May be used to treat meningeal carcinomatosis
- May be used as prophylaxis or treatment of meningeal lymphoma or leukemia.
- Both
- Neither
Methotrexate use:
- Treatment of choriocarcinoma
- Trophoblastic tumors in women
- Both
- Neither
Methotrexate in combination therapy may be beneficial in treating Burkitt's and other non-Hodgkin's lymphomas.
- True
- False
Notable toxicities of antifolate drugs include/includes:
- Intestinal epithelial toxicity
- Bone marrow toxicity
- Both
- Neither
Most widely employed agent for colorectal cancer treatment is 5-FU (5-fluorouracil).
- True
- False
Capecitabine (Xeloda):
- This agent is a prodrug.
- The 5'-deoxy-5-ffluorouridine metabolite is converted by thymidine phosphorylase to 5-FU in the tumor.
- Both
- Neither
Clinical application/applications of capecitabine:
- Metastatic breast cancer
- Adjuvant therapy in certain stages of colon cancer
- Treatment of metastatic colorectal cancer (monotherapy)
- A & B
- B & C
- A, B & C
Capecitabine + oxaliplatin (Xelox) is considered first-line treatment for metastatic colorectal cancer.
- True
- False
Primary toxicities associated with capecitabine involve diarrhea and hand-foot syndrome.
- True
- False