Medical Pharmacology: Cancer Chemotherapy Drugs: Anti-Metabolites Practice Questions

Low-dose methotrexate used continually for long-term treatment of psoriasis is associated with:
1. Cirrhosis
2. Nephrotoxicity
3. Both
4. Neither
Continue treatment with oral methotrexate for psoriasis may be associated with an increase in hepatic portal fibrosis which requires drug discontinuation.
1. True
2. False
Methotrexate when administered along with the prostaglandin analogue misoprostolIs highly likely to induce abortion and first-trimester pregnancies.
1. True
2. False
Erythematous and pruritic rash occurring with the frequency of about 40% is associated with this/these drug(s):
1. Pemetrexed
2. Methotrexate
3. Both
4. Neither
The deoxycytidine analogue which is considered the most important antimetabolite-type agent used to treat AML is cytarabine.
1. True
2. False
This agent is considered the single most effective drug for induction of clinical/complete remission in acute myelogenous leukemia.
1. Azacytidine
2. Cytarabine
3. Gemcitabine
The primary toxic metabolite derived from cytarabine (Ara-C):
1. 5'-mononucleotide (ara-CMP)
2. Ara-CTP
Mechanism(s) of anticancer effect associated with cytarabine:
1. Ara-CTP competitive inhibition of DNA polymerases-alpha, thus blocking DNA synthesis.
2. Ara-CTP competitive inhibition of DNA polymerases-ß, thus inhibiting DNA repair.
3. Both
4. Neither
Cytarabine (Ara-C) is considered a useful anticancer agent in which one(s) of the following conditions?
1. Acute lymphoblastic leukemia (ALL)
2. Chronic myelogenous leukemia (CML) in the blast phase
3. High-grade llymphoma
4. A & B
5. B & C
6. A, B & C
Administration of cytarabine (Ara-C) may result in profound myelosuppression.
1. True
2. False