Medical Pharmacology: Cancer Chemotherapy Drugs: Anti-Metabolites Practice Questions

Anticancer agents which work by damaging microtubules by this/these mechanism(s):
1. Destabilization of microtubules located away from the centriole.
2. Destabilization of the mitotic spindle
3. Both
4. Neither
Microtubule targeted anticancer drugs more likely effective in managing lung cancer, breast cancer, and hematological cancer.
1. Vinca alkaloids
2. Taxanes
Epothilone-analog, ixabepilone:
1. Metastatic breast cancer indication
2. Activity similar to taxanes but with limited taxing cross-resistance
3. Both
4. Neither
Newest class of microtubule-targeted anticancer drugs:
1. The vinca alkaloid class
2. The taxane class
3. The epothilone class
Vinblastine (Velban):
1. Alkaloid in nature; a derivative of the periwinkle plant, Vinca rosea
2. Inhibits tubulin polymerization, consequently inhibits proper microtubule assembly
3. Both
4. Neither
Vinblastine (Velban) as well as other Vinca alkaloids:
1. These agents are metabolized by the hepatic cytochrome P450 microsomal metabolizing system.
2. Most of the drug is excreted in the urine
3. Both
4. Neither
Adverse effect(s) associated with vinblastine administration include/includes:
1. Myelosuppression
2. Alopecia (hair loss)
3. Nausea/vomiting
4. A & B
5. B & C
6. A, B & C
Vinblastine (Velban), anticancer use(s):
1. Hodgkin's lymphoma
2. Non-Hodgkin's lymphoma
3. Both
4. Neither
Vincristine (Oncovin):
1. In combination with prednisone, vincristine may be used to induce remission in childhood acute lymphoblastic leukemia.
2. Vincristine exhibits activity for treating multiple myeloma.
3. Vincristine has shown efficacy in managing pediatric tumors such as neuroblastoma, Ewing's sarcoma, Wilms' tumor and rhabdomyosarcoma.
4. Vincristine has shown efficacy in managing pediatric tumors such as neuroblastoma, Ewing's sarcoma, Wilms' tumor and rhabdomyosarcoma.
5. A & B
6. B & C
7. A & C
8. A, B & C
9. A, B, C & D
Principal dose-limiting toxicity associated with vincristine administration:
1. Hepatic toxicity
2. Renal toxicity
3. Neurotoxicity
4. Cardiotoxicity