Medical Pharmacology: Cancer Chemotherapy Drugs: Anti-Metabolites (Anti-Microtubule) Practice Questions

Medical Pharmacology: Cancer Chemotherapy Anti-Metabolite (Anti-Microtubule) Practice Questions

Semisynthetic Vinca alkaloid analog(s):
1. Vinorelbine (Navelbine)
2. Vindesine (Eldesine)
3. Vinflunine (Javlor)
4. All of the above
Anticancer Vinca alkaloids utilize the intravenous route of administration, typically as a brief infusion.
1. True
2. False
Pharmacokinetic properties/properties associated with Vinca alkaloid anticancer drugs.
1. High clearance rates
2. Long half-lives
3. High volumes of distribution.
4. A & B
5. B & C
6. A & C
7. A, B & C
This Vinca alkaloid anticancer drug exhibits the longest terminal half-life with the slowest clearance rate.
1. Vinblastine
2. Vincristine
This Vinca alkaloid anticancer agent exhibits the shortest terminal half-life with the highest clearance rate.
1. Vinblastine
2. Vincristine
This agent exhibits a relatively low affinity for the microtubule component tubulin but appears more active compared other Vinca alkaloids with slow development of resistance.
1. Vinorelbine
2. Vinflunine
3. Vinblastine
Combination of Vinca alkaloids and mitomycin C:
1. Acute dyspnea
2. Bronchospasm
3. Both
4. Neither
Neutropenia represents the dose-limiting toxicity of which one(s) of the following drugs?
1. Vinblastine
2. Vinorelbine
3. Both
4. Neither
Vincristine neurotoxicity is particularly prominent in cranial nerves.
1. True
2. False
Which one(s) of the following agents exhibit comparable mechanisms of action?
1. Vinorelbine
2. Vinflunine
3. Vincristine
4. Vinblastine
5. All of the above