Medical Pharmacology: Cancer Chemotherapy Drugs: Anti-Tumor Antibiotics

Medical Pharmacology: Cancer Chemotherapy Anti-Tumor Antibiotics Practice Questions

Concerning Dactinomycin (actinomycin-D):
1. An example of the first anticancer antibiotics (actinomycins)..
2. Destroyed binds with double-helical DNA.
3. Both
4. Neither
Effect(s) of Dactinomycin-DNA-binding:
1. RNA polymerase directed DNA transcription is inhibited (blocked)
2. DNA polymerases are also inhibited by dactinomycin but to a lesser extent than RNA polymerases.
3. Dactinomycin induces single-strand DNA breaks
4. A & B
5. B & C
6. A & C
7. A, B & C
Dactinomycin crosses the blood brain barrier making the drug especially important in CNS neoplasm treatment.
1. True
2. False
Dactinomycin:
1. A very potent antitumor agent
2. Dactinomycin administration inhibits normal cellular proliferation.
3. Dactinomycin administration inhibits tumor cell proliferation.
4. A & B
5. B & C
6. A & C
7. A, B & C
Dactinomycin is extensively metabolized by the liver, utilizing the cytochrome P450 drug metabolism system.
1. True
2. False
Dactinomycin route/routes of administration:
1. Oral
2. Intramuscular
3. Intravenous
4. A & C
Most prominent clinical application/applications for dactinomycin in cancer treatment:
1. Treatment of Wilms tumor in children
2. Treatment of rhabdomyosarcoma
3. Both
4. Neither
Soft tissue sarcomas along with Ewing sarcoma and Kaposi sarcoma exhibit responsiveness to dactinomycin.
1. True
2. False
Common clinical toxicities associated with dactinomycin administration:
1. Diarrhea
2. Mucosal ulceration
3. glossitis
4. All of the above
Example(s) of dactinomycin toxicity noted soon after (a few hours) drug administration:
1. Nausea and vomiting
2. Anorexia
3. Both
4. Neither