Medical Pharmacology: Cancer Chemotherapy Drugs: Anti-Tumor Antibiotics

Medical Pharmacology: Cancer Chemotherapy Anti-Tumor Antibiotics Practice Questions

Anticancer antibiotic(s) isolated from Streptomyces peucetius var caesius:
1. Mitomycin
2. Doxorubicin
3. Bleomycin
4. Daunorubicin
5. A & B
6. B & C
7. B & D
8. A, B & C
9. All of the options are correct (A-D)
Mechanism/mechanisms accounting for cytotoxic effects of anthracycline antibiotics:
1. Topoisomerase II inhibition
2. DNA-binding (intercalation)
3. Free radical generation
4. Changing cellular membrane fluidity
5. A & B
6. B & C
7. B & D
8. A, B & C
9. All of the options are correct (A-D)
Anthracycline cardiotoxicity is likely mediated by free radical generation.
1. True
2. False
Anthracycline analogue(s):
1. Mitoxantrone (Novantrone)
2. Epirubicin (Ellence)
3. Idarubincin (Idamycin)
4. A & B
5. A & C
6. B & C
7. A, B & C
Multidrug resistance has been noted in tumors exposed to anthracycline antibiotic anticancer drugs.
1. True
2. False
Anthracycline antitumor agents, including their analogues: primary clearance mechanism
1. Renal excretion
2. Hepatic metabolism and biliary excretion
3. Both equally prominent
4. Neither
Anthracyclines including their active alcohol metabolites exhibit delayed clearance in the presence of renal dysfunction.
1. True
2. False
Idarubincin administration results in reduced cardiotoxicity compared with other anthracycline-type anticancer agents.
1. True
2. False
Red color in the year and is expected following daunorubicin administration.
1. True
2. False
Daunorubicin and Idarubincin are often administered along with cytarabine (Ara-C) for treatment of acute myelogenous leukemia (AML).
1. True
2. False