Medical Pharmacology: Antiviral Drug Practice Questions

Medical Pharmacology: Antiviral Drug Practice Questions

Acyclovir (Cyclovir, Zovirax and Others)

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Herpes simplex 2 (HSV-2) is typically associated with:
1. Genital and rectal infections
2. Mouth, esophagus, brain disease
3. Both
4. Neither
Drugs that are used to treat HSV (herpes simplex virus) usually:
1. Inhibit host cell viral DNA replication
2. Inhibit host cell transport of metabolized drug from the cytoplasm to the nucleus.
3. Both
4. Neither
Acyclovir:
1. A guanine nucleoside analog
2. Prototype of antiviral agents classified as nucleoside congeners.
3. Both
4. Neither
Acyclovir is an example of an antiviral drug (nucleoside congeners) which is phosphorylated and the phosphorylated form is capable of viral DNA synthesis inhibition.
1. True
2. False
Acyclovir phosphorylation:
1. Involves a viral kinase
2. Involves host cell kinases
3. Both
4. Neither
This/these agents is/are related to acyclovir:
1. Penciclovir (Denavir)
2. Ganciclovir (Cytovene)
3. Both
4. Neither
Acyclovir (guanine analogue) inhibits both mammalian DNA polymerase and viral DNA polymerase
1. True
2. False
Acyclovir in Herpes Simplex Virus is not subject to resistance mechanisms.
1. True
2. False
Most likely mechanism of acyclovir resistance in clinical isolates is associated with reduced/absent viral thymidine kinase enzyme activity.
1. True
2. False
Acyclovir resistant variants:
1. Found in native virus populations
2. Found in viral isolates from "treated patient."
3. Both
4. Neither

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Source Material:

Acosta EP Chapter 62 Antiviral Agents (Nonretroviral) in Goodman & Gilman's: The Pharmcological Basis of Therapeutics, 14e, (Brunton LL Knollmann BC eds) McGraw-Hill Education, 2023.

Safrin S Chapter 49 Antiviral Agents in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah TW, Associate editor) 15e McGraw Hill 2021.

Li JZ Coen DM Chapter 38 Pharmacology of Viral Infections in Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy 4e (Golan DE Armstong EJ Armstrong AW, eds) Wolters Kluwer 2017.

Waller DB Sampson AP Section 11 Chemotherapy in Medical Pharmacology & Therapeutics Elsevier 2018.

Burchum JR Rosenthal LD Chapter 97 Antiviral Agents I: Drugs for Non-HIV Viral Infections in Lehne's Pharmacology for Nursing Care Elsevier 2022.

Waller DB Sampson AP Section 11: Chapter 51 Chemotherapy of infections in Medical Pharmacology & Therapeutics Elsevier 2018.

Benavides S Bahal O'Mara N Nahata MC Chapter 79 Viral Infections in Applied Therapeutics: The Clinical Use of Drugs (Zeind C, Carvalho MG Cheng JW Zaiken K Lapointe T, eds} Wolters Kluwer, 2024.