For patients in the hospital due to "severe primary genital" herpes simplex viral infections: IV acyclovir administration would likely lead to a decrease in healing time and viral shedding.
True
False
Use of acyclovir or valacyclovir in treating initial genital HSV viral infections is the added benefit of
preventing recurrent genital lesions.
True
False
Oral acyclovir administration is more effective in treating:
Primary herpetic gingivostomatitis
Orolabial herpes
Both treatments equally effective
Use of topical acyclovir cream:
Effective in recurrent labial HSV infections. (Modestly effective).
Effective in treating genital HSV viral infections.(Modestly effective)
Both
Neither
During the last month of pregnancy, acyclovir administration
increases viral shedding in patients with primary/recurrent genital herpes.
True
False
Acyclovir administration in patients with primary/recurrent genital herpes appears to reduce the likelihood of cesearean delivery.
True
False
Prevention of mucocutaneous HSV infections in seropositive individuals, undergoing immunosuppression, may greatly benefit by systemic acyclovir prophylaxis. [Acosta EP Chapter 62 Antiviral Agents (Nonretroviral) in Goodman & Gilman's: The Pharmcological Basis of Therapeutics]
True
False
In patients who are immunocompromised, acyclovir-resistant human simplex viruses may be associated with:
Meningoencephalitis
Substantial mucocutaneous disease
Both
Neither
Ophthalmic acyclovir appears comparably effective compared to vidarabine or trifluridine in
treating herpetic keratoconjunctivitis.
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Source Material:
Acosta EP Chapter 62 Antiviral Agents (Nonretroviral)
in Goodman & Gilman's: The Pharmcological
Basis of Therapeutics, 14e, (Brunton LL Knollmann BC eds) McGraw-Hill Education, 2023.
Safrin S Chapter 49 Antiviral Agents
in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah
TW, Associate editor) 15e McGraw Hill 2021.
Li JZ Coen DM Chapter 38 Pharmacology of
Viral Infections in Principles of Pharmacology:
The Pathophysiologic Basis of Drug Therapy 4e (Golan DE
Armstong EJ Armstrong AW, eds) Wolters Kluwer 2017.
Waller DB Sampson AP Section 11
Chemotherapy in Medical Pharmacology & Therapeutics
Elsevier 2018.
Burchum JR Rosenthal LD Chapter 97
Antiviral Agents I: Drugs for Non-HIV Viral Infections
in Lehne's Pharmacology for Nursing Care Elsevier 2022.
Waller DB Sampson AP Section 11: Chapter
51
Chemotherapy of infections in Medical Pharmacology & Therapeutics
Elsevier 2018.
Benavides S Bahal O'Mara N Nahata MC
Chapter 79 Viral Infections in Applied Therapeutics:
The Clinical Use of Drugs (Zeind C, Carvalho MG Cheng JW
Zaiken K Lapointe T, eds} Wolters Kluwer, 2024.
