Medical Pharmacology: Antiviral Drug Practice Questions
Click on the correct answer.
Letermovir (Prevymis):
Curative treatment for cytomegalovirus infections.
Classified as a CMV DNA terminase complex inhibitor.
Both
Neither
Route/routes of administration:
Oral administration
IV infusion
Both
Neither
Clinical use/uses for letermovir
Management of disease in adult CMV-seropositive recipients of an allogenic hematopoietic stem cell transplantation (HSCT)
CMV prophylaxis
Both
Neither
Letermovir: probably most recently, newly licensed antiviral drug exhibiting
anti-cytomegalovirus infection efficacy.
True
False
Letermovir in combination with ganciclovir may be useful in managing neonatal (symptomatic) congenital CMV disease.
True
False
Letermovir administration:
IV administration using a central venous line or peripheral catheter over about a one hour timeframe
IV bolus injection
Both
Neither
Dosage of letermovir should be adjusted in which one(s) of the following:
When coadministered with cyclosporine.
In patients with renal impairment with creatinine clearance >10 mls/min.
Both
Neither
Letermovir exhibits cross-resistance to the following other CMV antiviral agents: cidofovir, ganciclovir, and foscarnet.
True
False
In CMV-seropositive recipients of allogenic hematopoietic stem cell transplants, letermovir was better than placebo in preventing clinically significant cytomegalovirus infections, at least through
6 month following transplantation.
True
False
Notable side effect/effects associated with letermovir administration:
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Source Material:
Acosta EP Chapter 62 Antiviral Agents (Nonretroviral)
in Goodman & Gilman's: The Pharmcological
Basis of Therapeutics, 14e, (Brunton LL Knollmann BC eds) McGraw-Hill Education, 2023.
Safrin S Chapter 49 Antiviral Agents in
Basic & Clinical Pharmacology (Katzung BG, Editor;
Vanderah TW, Associate editor) 15e McGraw Hill 2021.
Li JZ Coen DM Chapter 38 Pharmacology of
Viral Infections in Principles of Pharmacology:
The Pathophysiologic Basis of Drug Therapy 4e (Golan DE
Armstong EJ Armstrong AW, eds) Wolters Kluwer 2017.
Waller DB Sampson AP Section 11
Chemotherapy in Medical Pharmacology & Therapeutics
Elsevier 2018.
Burchum JR Rosenthal LD Chapter 97
Antiviral Agents I: Drugs for Non-HIV Viral Infections
in Lehne's Pharmacology for Nursing Care Elsevier 2022.
Waller DB Sampson AP Section 11: Chapter
51
Chemotherapy of infections in Medical Pharmacology & Therapeutics
Elsevier 2018.
Benavides S Bahal O'Mara N Nahata MC
Chapter 79 Viral Infections in Applied Therapeutics:
The Clinical Use of Drugs (Zeind C, Carvalho MG Cheng JW
Zaiken K Lapointe T, eds) Wolters Kluwer, 2024.
Davanathan AS Symonds AE Adams JL
Cottrell ML Chapter 76 Pharmacotherapy of Human
Immunodeficiency Virus Infection
in Applied
Therapeutics: The Clinical Use of Drugs (Zeind C, Carvalho MG Cheng JW
Zaiken K Lapointe T, eds) Wolters Kluwer, 2024.
