Medical Pharmacology: Antiviral Drug Practice Questions

Adverse effect/effects: acyclovir
1. Oral acyclovir administration may rarely induce nausea or headache.
2. Oral acyclovir may also very rarely cause neurotoxicity or renal dysfunction.
3. Both
4. Neither
Unlikely but serious thrombocytopenic reactions in immunocompromised patients appear associated with valacyclovir administration.
1. True
2. False
This/these side effects associated with intravenous acyclovir represent dose-limiting toxic reactions.
1. Side effects referable to the central nervous system
2. Renal insufficiency
3. Both
4. Neither
Neutropenia in neonates may occur following acyclovir administration.
1. True
2. False
Topical cidofovir application:
1. Application site reactions including pain and pruritus.
2. Ulceration (probably infrequent)
3. Both
4. Neither
Adverse effect(s) associated with oral famciclovir administration:
1. Headache
2. Nausea and diarrhea
3. Confusion
4. A & B
5. B & C
6. A & C
7. A, B & C
Main dose-limiting toxic reaction to ganciclovir administration.
1. Myelosuppression
2. GI distress
3. Cardiovascular insufficiency
4. Pulmonary hyperplasia
Management of neutropenia due to penciclovir administration may include administration of granulocyte colony-stimulating factor e.g. filgrastim, lenograstim, G-CSF.
1. True
2. False
CNS toxicities associated with IV ganciclovir administration leads to early discontinuation of IV treatment secondary to CNS toxicity or bone marrow toxicities.
1. True
2. False
Primary dose-limiting toxicity-toxicities associated with foscarnet includes/includes:
1. Hypocalcemia
2. Nephrotoxicity
3. Both
4. Neither