Medical Pharmacology: Antiviral Drug Practice Questions

Cidofovir (Vistide):
1. Good penetration into the CSF
2. Exceedingly low oral bioavailability
3. Both
4. Neither
The active form of cidofovir is cidofovir diphosphate.
1. True
2. False
Cidofovir diphosphate
1. Extended half-life (intracellular)
2. Competitive inhibitor of both HSV (herpes simplex virus) and CMV (cytomegalovirus) DNA polymerases
3. Both
4. Neither
Cidofovir clearance:
1. Renal clearance (glomerular filtration and tubular secretion)
2. Most of the drug (greater than 90% can be found in the urine unchanged.
3. Both
4. Neither
Probenecid effects on cidofovir tubular transport:
1. Blocks tubular transport
2. Increases renal clearance while diminishing nephrotoxicity
3. Both
4. Neither
Therapeutic use/uses of intravenous cidofovir:
1. Acyclovir-resistant mucocutaneous herpes simplex viral infections
2. Adenovirus disease in patients who have received a transplant.
3. Both
4. Either
Probenecid and changes in drug renal clearance:
1. Probenecid does not affect renal clearance of cidofovir
2. Probenecid decreases zidovudine (AZT) clearance.
3. Both
4. Neither
Zidovudine gel (topical) effectively eliminates virus shedding as well as lesions in a subset of HIV-infected patients also exhibiting acyclovir-resistant mucocutaneous HSV infections.
1. True
2. False
Intralesional administered zidovudine promotes remission in both children and adults with respiratory papillomatosis.
1. True
2. False
Cidofovir antiviral activity is noted in which one/ones of the following?
1. Papilloma
2. Pyloma
3. Adenoviruses
4. A & B
5. B & C
6. A & C
7. A, B & C