Medical Pharmacology: Antiviral Drug Practice Questions

Cidofovir (Vistide):
1. Classified as an anti-herpesvirus nucleotide analog.
2. Similar to deoxycytidine monophosphate; cidofovir is a phosphate-containing cytosine analog (phosphonate).
3. Both
4. Neither
Cidofovir, by contrast to acyclovir for example, does not require viral kinases for phosphorylation.
1. True
2. False
Cidofovir (Vistide):
1. Active against viruses resistant to ganciclovir.
2. Typically given by oral administration.
3. Both
4. Neither
In the context of both prophylaxis and management of end-organ cytomegalovirus disease, this drug has reduced the therapeutic use of IV administered agents.
1. Ganciclovir
2. Foscarnet
3. Valganciclovir
4. Cidofovir
Appropriate drug/drugs for treating retinitis due to cytomegalovirus (CMV) infections:
1. Ganciclovir
2. Foscarnet
3. Valganciclovir (Valcyte)
4. Cidofovir
5. A & B
6. B & C
7. A & C
8. D only
9. A, B, C & D
Specifically appropriate for prophylaxis of CMV infection and disease in adults CMV-seropositive recipients of allogenic hematopoietic stem cell transplants.
1. Foscarnet
2. Letermovir (Prevymis)
3. Both
4. Neither
Reduction of dosage not required in patients with renal insufficiency:
1. Cidofovir
2. Valganciclovir
3. Letermovir
4. Foscarnet
5. All of the above agents require dosage reduction for those patients with renal insufficiency.
Primary dose-limiting IV cidofovir side effect:
1. Hepatotoxicity
2. Renal toxicity
3. Pulmonary toxicity
4. Cardiac toxicity
Cidofovir resistance in cytomegalovirus infections is typically due to mutations affecting viral DNA polymerase.
1. True
2. False
Foscarnet-resistant cytomegalovirus isolates are likely cross resistant to cidofovir.
1. True
2. False