Medical Pharmacology Chapter 5: Pharmacology of Adrenergic Drugs

Concerning epinephrine (adrenaline):
1. Activates α receptors
2. Activates ß receptors
3. Especially notable effects on the heart, vascular system and other smooth muscle
4. A & B
5. B & C
6. A & C
7. A, B & C
Concerning epinephrine as a vasopressor agent:
1. One of the most potent
2. By IV administration, epinephrine induces peak response proportional to dose..
3. By the administration, increase in systolic pressure is less than the increase in diastolic pressure.
4. A & B
5. B & C
6. A & C
7. A, B & C
Factor/factors associated with characterizing blood pressure increases secondary to epinephrine administration:
1. Increase in blood pressure is due in part to increased ventricular contractility (also known as a positive inotropic effect)
2. Increase in blood pressure is due in part to increased heart rate (also known as positive chronotropic effect)
3. Both
4. Neither
Following IV epinephrine administration,an increased blood pressure is observed in part because of drug-induced vasoconstriction, particularly in skin, mucosal, and renal precapillary resistance vessels.
1. True
2. False
Following IV epinephrine administration, the pulse rate is initially increased but may then be decreased as a result of a compensatory cholinergic, vagal effect triggered by the baroreceptor reflex.
1. True
2. False
Absorption of epinephrine following subcutaneous (s. c.) injection: slows result of local vasoconstrictor activity mediated by β receptor activation.
1. True
2. False
Administration of this agent by the intravenous infusion route is likely to cause an immediate reduction in pulse rate. (over time range of 15 min.; 10μg/min)
1. Norepinephrine
2. Epinephrine
3. Isoproterenol
IV administration of this agent is likely to result in an extended elevation in heart rate. (over time range of 15 min..; 10μg/min)
1. Norepinephrine
2. Epinephrine
3. Isoproterenol
IV administration of this agent is most likely to induce both in elevation in systolic and diastolic pressures. (over time range of 15 min..; 10μg/min)
1. Norepinephrine
2. Epinephrine
3. Isoproterenol
IV administration of this agent is most likely to result in an extended elevation in vascular peripheral resistance. (over time range of 15 min..; 10μg/min)
1. Norepinephrine
2. Epinephrine
3. Isoproterenol
IV administration of this agent is most likely to cause the most profound decrease in diastolic blood pressure. (over time range of 15 min..; 10μg/min)
1. Norepinephrine
2. Epinephrine
3. Isoproterenol
IV administration of this agent is least likely to cause an increase in systolic blood pressure. (over time range of 15 min..; 10μg/min)
1. Norepinephrine
2. Epinephrine
3. Isoproterenol
IV administration of this agent is most likely to result in the most profound decrease in peripheral resistance. (over time range of 15 min..; 10μg/min)
1. Norepinephrine
2. Epinephrine
3. Isoproterenol

"Comparative effects of intravenous infustion of NE, EPI, and INE"

"Comparative effects of intravenous infustion of NE, EPI, and INE" *(c) Brunton LL Hilal-Dandan Knollmann BC: Goodman & Gilman's: The Pharmacology Basis of Therapeutics, Thirteenth Edition; Copyright (c) McGraw-Hill Education. All Rights reserved; Original citation: Allwood MJ Cobbold AF Ginsberg J. Peripheral vascular effects of noradrenaline, isopropylnoradrenaline and dopamine. Br Med Bull. 1963; 19;132-136, Oxford University Press).