Medical Pharmacology Practice Questions: Antiarrhythmic Drugs

At high (toxic levels) concentrations of quinidine which one(s) of the following side effects may be observed?
1. Tinnitus
2. Dizziness
3. Headache
4. All of the above
The cardiac effects of disopyramide are very similar to which one(s) of the following antiarrhythmic drugs?
1. Lidocaine
2. Quinidine
3. disopyramide
4. A & B
5. B & C
6. A, B & C
Disopyramide exhibits a greater anticholinergic, antimuscarinic effect compared to quinidine.
1. True
2. False
Therapeutic use of disopyramide include management of which one(s) of the following conditions?
1. Reduce the likelihood of recurring ventricular tachycardia or ventricular fibrillation.
2. Maintenance of normal sinus rhythm in patients exhibiting atrial flutter or atrial fibrillation
3. Both
4. neither
Similar to quinidine, disopyramide exhibits alpha-adrenergic receptor antagonism which causes a hypotensive response following disopyramide administration.
1. True
2. False
Anti-cholinergic effects associated with disopyramide administration include which one(s) of the following?
1. Prostatism
2. Glaucoma
3. Dry mouth
4. Constipation
5. A &C
6. B & C
7. D only
8. A, B, C and D
Disopyramide route(s) of elimination:
1. Liver metabolism
2. Renal excretion
3. Both
4. Neither
Disopyramide administration in a patient with renal dysfunction may require which one of the following dose adjustments?
1. increase in disopyramide dose.
2. Reduction in disopyramide dose
3. No dose adjustment is required
Which one(s) of the following statements concerning disopyramide toxicity is/are correct?
1. Disopyramide administration can cause a positive inotropic effect i.e. increased contractility.
2. Disopyramide administration may induced heart failure in patients not previously having presented with CHF.
3. Disopyramide administration may cause heart failure in patients with pre-existing depressed left ventricular function.
4. A & B
5. B & C
6. A, B & C
In the United States, disopyramide is approved for the treatment of which one(s) of the following conditions?
1. Supraventricular arrhythmias
2. Ventricular arrhythmias
3. Both
4. Neither