Medical Pharmacology Practice Questions

Nondihydropyridine calcium channel antagonists specifically antagonize calcium-dependent slow action potentials in both the sinoatrial and AV nodes.
1. True
2. False
Example(s) of nondihydropyridine calcium channel blocker(s):
1. Diltiazem
2. Verapamil
3. Both
4. Neither
Pharmacological and electrophysiological effect(s) of diltiazem may include(s):
1. Lengthening of the AV nodal refractory period.
2. Peripheral vasoconstriction
3. Both
4. Neither
Which one(s) of the following pharmacokinetic/dosing characteristics of diltiazem and verapamil is/are correct?
1. Oral administration is associated with bioavailability on the order of 40%.
2. Both drugs are susceptible to first pass hepatic metabolism.
3. The principal route of elimination is renal.
4. A only
5. B & C
6. A & B
7. A, B & C
Therapeutic applications of diltiazem and verapamil include which one(s) of the following?
1. Termination of supraventricular tachycardia
2. Prevention of supraventricular tachycardia recurrence
3. Management of ventricular rate in the presence of atrial fibrillation/flutter.
4. A & B
5. A, B & C
Diltiazem administration may prevent ventricular fibrillation secondary to coronary artery vasospasm.
1. True
2. False
Verapamil and diltiazem (IV administration) is effective in management of Wolff-Parkinson-White syndrome when complicated by atrial fibrillation.
1. True
2. False
Verapamil must be administered with caution in those patients exhibiting impaired renal perfusion with renal dysfunction.
1. True
2. False