Medical Pharmacology Practice Questions: Antihypertensive Drugs

All ß-antagonists exhibit similar antihypertensive potencies.
1. True
2. False
Administration of which one of the following ß-antagonists increase nitric oxide release?
1. Metoprolol
2. Nebivolol
3. Propranolol
4. Carvedilol
Which one(s) of the following drugs mediate antihypertensive effects in part by alpha-adrenergic receptor blockade?
1. Propranolol
2. Pindolol
3. Carvedilol
Which one of the following ß-adrenergic antagonists does not appear to exhibit ß-1 selectivity?
1. Acebutolol
2. Atenolol
3. Bisoprolol
4. Labetalol
5. Metoprolol
Abrupt discontinuation of ß-adrenergic receptor antagonists may result in which one(s) of the following adverse effects?
1. Worsening of symptoms caused by coronary artery pathology
2. Rebound hypertension
3. Both
4. Neither
Indomethacin may reduce antihypertensive effects of propranolol (Inderal).
1. True
2. False
Long-term treatment with alpha-1 adrenergic receptor antagonists is associated with which one(s) of the following effects?
1. Increase in heart rate
2. Increase in plasma renin activity
3. Vasodilation
4. All of the above
5. None of the above
A significant precaution associated with using alpha-1 blockers for hypertensive management is the "first-dose phenomenon" characterized principally by which one of the following?
1. Reduced renin secretion
2. Orthostatic hypotension
3. Paradoxical hypertensive response
4. None of the above
Use of alpha-1 receptor antagonists is particularly helpful in treating hypertension secondary to pheochromocytoma.
1. True
2. False
Which one(s) of the following drugs exhibit both alpha-1 adrenergic receptor blockade and ß-adrenergic receptor blockade?
1. Labetalol
2. Carvedilol
3. Both
4. Neither