Medical Pharmacology Practice Questions: Antihypertensive Drugs

Choose the correct statement concerning calcium channel blockers.
1. Calcium channel blockers reduce blood pressure by reducing arteriolar smooth muscle tone whilel slightly increasing peripheral vascular resistance.
2. A sympathetic, baroreceptor caused increase in cardiac sympathetic nerve activity is likely to occur following administration of calcium channel antagonists.
3. ß-receptor antagonists which reduce heart rate may have this effect blocked if diltiazem is also administered..
4. None of the above statements are correct
Calcium channel antagonists may be effective if used as monotherapy (only drug used) or in combination with other drugs for management of hypertension..
1. True
2. False
Nifedipine (or other dihydropyridine) calcium channel antagonist with short half-lives administered in standard, immediate-release formulations are especially clinically appropriate in treating hypertension
1. True
2. False
When used as monotherapy calcium channel antagonists may be more likely, compared other agents, to obtain blood pressure control in which one(s) of the following groups.
1. African-Americans patients due to a higher prevalence of low renin levels.
2. Elderly patients
3. Both
4. Neither
Which one(s) of the following side effects of calcium channel antagonists are classified as common side effects?
1. Headache
2. Bradycardia
3. Constipation
4. Peripheral edema
5. A & B Only
6. A, B, C & D
Edema associated with Ca2+ channel blocker administration may be reduced by coadministering which one(s) of the following?
1. Angiotensin-converting enzyme inhibitors (ACE inhibitors)
2. Angiotensin receptor blockers
3. Both
4. Neither
Which calcium channel antagonist exhibits "establish safety" for use in patients with severe heart failure?
1. Nifedipine
2. Verapamil
3. Nicardipine
4. Amlodipine
5. Felodipine
Administration of calcium channel antagonists exhibits a "protective effect against stroke."
1. True
2. False
Which one(s) of the following calcium channel antagonists, classified as antihypertensive drugs, are also approved for use in managing angina?
1. Amlodipine
2. Nicardipine
3. Nifedipine
4. None of the above
5. A,B,C
Which one of the following calcium channel antagonists is the most likely to reduce cardiac automaticity and conduction velocity?
1. Amlodipine
2. Diltiazem
3. Felodipine
4. Isradipine
5. None of the above