Medical Pharmacology Practice Questions: Drugs for Lowering Lipid Levels

Which one(s) of the following statements concerning niacin is/are correct?
1. Niacin increases VLDL secretion
2. Niacin decreases LDL production
3. Both
4. Neither
Administration of niacin in combination with a reductase inhibitor (statin) or a resin-type agent usually results in normal LDL levelsin patients with heterozygous familial hypercholesterolemia.
1. True
2. False
Which one of the following represents the major statin-associated adverse effect?
1. hepatotoxicity
2. Excessively low LDL levels
3. Myopathy
4. Renal dysfunction
The likelihood of rhabdomyolysisfollowing statin administration is not correlated with either dose or plasma concentration.
1. True
2. False
Niacin is a B-complex vitamin.
1. True
2. False
Major niacin side effect(s) is/are limiting with respect to patient compliance.
1. Dyspepsia
2. Flushing
3. Both
4. Either
The most common and serious side effect associated with niacin administration is:
1. Renal toxicity
2. Blood dyscrasias
3. Hepatotoxicity
4. Pulmonary fibrosis
Niacin administration may be associated with induced insulin resistance that can cause severe hypoglycemia.
1. True
2. False
Niacin may be helpful in treating hypertriglyceridemia as well as high LDL-C.
1. True
2. False
Renal failure and hepatic dysfunction are two conditions that represent a relative contraindication to administration of fibric acid-type drugs.
1. True
2. False