Medical Pharmacology Practice Questions: Drugs for Lowering Lipid Levels

This statin has been approved for children eight years or older for use in the presence of heterozygous familial hypercholesterolemia.
1. Pitavastatin
2. Atorvastatin
3. Lovastatin
4. Simvastatin
Statins used in combination with bile acid-binding resins decrease LDL-C by 20%-30% compared to statins alone.
1. True
2. False
(An) example(s) of bile acid-binding resins useful in managing elevated cholesterol levels:
1. Colestipol
2. Cholestyramine
3. Both
4. Neither
Choose the correct statement(s) concerning combination of gemfibrozil with a statin.
1. Combination of gemfibrozil with a statin may be particularly helpful for treatment of combined hypertriglyceridemia with high LDL-C levels.
2. Combination of a fibrate such as gemfibrozil and a statin reduces risk of myopathy even at hi statin dose levels.
3. Both
4. Neither
Fenofibrate has been suggested as the safest fibrate to use with statins possibly because it is the fibrate least likely to affect statin metabolism.
1. True
2. False
Concerning drug combinations, which one(s) of the following is/are correct?
1. Triple therapy using niacin, statins and resins may decrease LDL-C up to 70%.
2. Combination of simvastatin (fixed dose) and ezetimibe has been demonstrated to reduce LDL-C levels up to 60% (at 24 weeks).
3. Both
4. Neither
Which one(s) of the following bile-acid sequestering agents or resins is/are likely very safe, since no intestinal absorption occurs.
1. Cholestyramine
2. Colestipol
3. Both
4. Neither
Either statins or bile-acid sequestrants are considered first-line agents due to comparable efficacy.
1. True
2. False
Administration of bile-acid sequestering agents increases hepatic bile-acid synthesis.
1. True
2. False
Severe hypertriglyceridemia is considered a contraindication to cholestyramine or colestipol administration since these agents increase triglyceride levels.
1. True
2. False