Medical Pharmacology Practice Questions: Anti-Depressant Drugs

This drug used to treat depressive disorder is associated with the risk of tardive dyskinesia with long-term use.
1. Maprotiline
2. Bupropion
3. Sertraline
4. Amoxapine
Presenting characteristic(s) associated with "serotonin syndrome"
1. Myoclonus
2. Abdominal cramping
3. Hypertension
4. Hyperpyrexia
5. All of the above
Fluoxetine, paroxetine, citalopram and escitalopram, compared to tricyclic antidepressants:
1. Exhibit increased anticholinergic and sedating effects
2. Exhibit reduced likelihood of gastrointestinal difficulties and sleep impairment
3. Both
4. Neither
Selective serotonin reuptake inhibitors (SSRIs) administration may be associated with which one(s) of the following effects?
1. Enhance libido
2. Impotence
3. Difficulty in reaching orgasm
4. A & B
5. B & C
6. A & C
7. A, B, & C
Escitalopram:
1. Highly specific compared to other SSRIs
2. Potent inhibitor of the cytochrome P450 microsomal drug metabolizing system
3. Both
4. Neither
SSRIs are effective antidepressant medications; however, these agents are only sparingly lipophilic which reduces their CNS access.
1. True
2. False
Venlafaxine, an SNRI (selective serotonin-norepinephrine reuptake inhibitor)exhibits a similar in vivo activity compared to imipraminebut shows a more favorable adverse-effect profile.
1. True
2. False
SNRIs (selective norepinephrine and serotonin reuptake inhibitors) as well as TCAs bind to serotonin and norepinephrine transporters.
1. True
2. False
Administration of this agent is more likely to cause substantial anticholinergic (antimuscarinic) side effects.
1. Desipramine
2. Imipramine
3. Both about the same
Currently, bicyclic antidepressants (TCAs) are more likely to be used in patients whose depression does not respond to the more commonly used agents such as SNRIs and SSRIs.
1. True
2. False