Medical Pharmacology Practice Questions: Anti-Depressant Drugs

Relatively specific antidepressant actions were first associated with this drug class:
1. Tricyclic antidepressants (TCAs)
2. Monoamine oxidase inhibitors (MAOI s)
3. Selective serotonin reuptake inhibitors (SSRIs)
4. Selective norepinephrine serotonin reuptake inhibitors (SNRIs)
Which one of the following drugs is not classified as a monoamine oxidase inhibitor?
1. Phenelzine
2. Maprotiline
3. Tranylcypromine
4. Isocarboxazid
Agents such as phenelzine and tranylcypromine "irreversibly" inhibit the enzymatic activity of MAO-A and MAO-B.
1. True
2. False
This selective MAO-B inhibitor has been shown useful in managing Parkinson's disease.
1. Moclobemide
2. Selegiline
3. Imipramine
4. Fluoxetine
Imipramine, exhibiting a phenothiazine-like structure,exhibits efficacy both in treating depression and schizophrenia.
1. True
2. False
Of these agents, which one exhibit some enhanced selectivity for serotonin uptake inhibition?
1. Clomipramine
2. Amitriptyline
3. Doxepin
4. Imipramine
Norepinephrine reuptake inhibitor clinically employed to manage attention deficit hyperactivity disorder (ADHD).
1. Imipramine
2. Tranylcypromine
3. Atomoxetine
This selective serotonin reuptake inhibitor has been approved by the FDA for managing obsessive-compulsive disorder along with social anxiety disorder but not for management of depression.
1. Sertraline
2. Fluvoxamine
3. Citalopram
4. Escitalopram
Selective serotonin reuptake inhibitors (SSRIs) appear clinically effective in which one/ones of the following?
1. Anxiety
2. Major depression
3. Both
4. Neither
Which one(s) of the following agents is/are approved for treating posttraumatic stress disorder (PTSD)?
1. Sertraline
2. Paroxetine
3. Both
4. Neither