Medical Pharmacology:
Anti-Seizure; Anti-Epilepsy Drug Practice Questions
Click on the correct answer.
Fosphenytoin is phenytoin prodrug which is more soluble then the parent compound.
- True
- False
Adverse effect(s) associated with phenytoin administration:
- Osteomalacia
- Morbilliform rash
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- A & C
- A, B & C
- A, B, C & D
Mothers receiving phenytoin during pregnancy may give birth to newborns who exhibit hypoprothrombinemia and hemorrhage.
- True
- False
Concerning the dose-dependent phenytoin elimination kinetics:
- At low phenytoin concentration first-order kinetics is observed
- At higher doses still within the therapeutic range, hepatic metabolizing system saturation begins to occur
- Both
- Neither
Phenytoin half-life:
- 1-3 hours
- 5-10 hours
- 12-36 hours
- 72 hours
Phenytoin bioavailability and absorption rate is generally independent of the particular preparation.
- True
- False
May be effective in treating trigeminal neuralgia:
- Phenytoin
- Carbamazepine
- Both
- Neither
Most frequently encountered cause for low phenytoin plasma levels:
- Increased phenytoin metabolism as a result of administration of other drugs.
- Decreased intestinal absorption
- Poor patient compliance
Phenytoin administration may reduce the reliability of thyroid function screening tests.
- True
- False
Long-term effects of phenytoin treatment include/includes:
- Facial feature coarsening
- Some peripheral neuropathy
- Both
- Neither
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