Medical Pharmacology Chapter 19:
Anti-Seizure; Anti-Epilepsy Drug Practice Questions
Click on the correct answer.
Which one(s) of the following drugs (phenytoin-like) they appear efficacious in the management of both partial seizures in generalized tonic-clonic seizures?
Mephenytoin
Ethotoin
Both
Neither
Choose (the) correct statement(s) concerning the pharmacology of ethotoin.
May be appropriate for patients exhibiting phenytoin hypersensitivity.
Ethotoin may be less effective compared to phenytoin
Ethotoin associated adverse effects/toxicities appear less severe compared to those noted with phenytoin administration.
Ethotoin associated adverse effects/toxicities appear less severe compared to those noted with phenytoin administration.
A & B
B only
B & C
A only
A & C
A, B & C
Within the therapeutic dosage range, mesantoin and ethotoin both exhibit saturable, zero order kinetics, as noted with phenytoin.
True
False
Most of the anti-seizure effectiveness of mesantoin is due to its metabolite, Nirvanol.
True
False
Possible indication(s) for the therapeutic use of carbamazepine include(s):
Seizures
Management of bipolar depressive disorder
Trigeminal neuralgia
A & B
B & C
A, B & C
Choose the correct statement(s) concerning carbamazepine clinical utility/utilities.
Agent of choice in treating generalized tonic-clonic seizures and partial seizures
Carbamazepine when administered in typical therapeutic doses is often highly sedating.
Higher doses administered to elderly patients may be associated with unsteadiness and ataxia
A & B
B & C
A & C
A, B & C
Half-life following a single initial dose of carbamazepine:
3 hours
9 hours
12 hours
36 hours
Most common dose-related carbamazepine adverse effects: ataxia and diplopia.
True
False
Most common idiopathic reaction to carbamazepine administration: erythematous skin rash.
True
False
Idiopathic blood dyscrasias associated with carbamazepine administration may occur and may include potentially fatal aplastic anemia and agranulocytosis.