Medical Pharmacology Practice Questions: Anti-Seizure; Anti-Epileptic Drugs

Probably the principal ion-channel involved in anti-seizure effects of gabapentin.
1. Decreased rate of activation of sodium-channel
2. Reducing calcium entry following binding to voltage-gated N-type calcium channels
3. Reducing the rate of potassium reflux following depolarization.
Neurotransmitter system most likelyresponsible for anti-seizure activity following administration of gabapentin and pregabalin.
1. Muscarinic cholinergic (acetylcholine)
2. Alpha-adrenergic (norepinephrine)
3. Glutaminergic (glutamate)
4. Serotonergic (serotonin)
Gabapentin clinical use as an anti-seizure medication:
1. Effective in managing generalized tonic-clonic seizures
2. Adjuvant medication for management of partial seizures
3. Both
4. Neither
Common adverse effect(s) associated with gabapentin administration:
1. Sleepiness
2. Dizziness
3. Headache
4. Tremor
5. A & B
6. B & C
7. A, B & C
Pregabalin has been approved as an adjunct medication in treating partial seizures (with or without secondary generalization).
1. True
2. False
Clinical application(s) of pregabalin:
1. Neuropathic pain
2. Fibroneuralgia
3. Generalized anxiety
4. A & B
5. B & C
6. A & C
7. A, B & C
Gabapentin administration does not result in liver enzyme induction and is not subject to metabolism.
1. True
2. False
Neither metabolized and principally, nearly completely, excreted in the urine unchanged.
1. Gabapentin
2. Pregabalin
3. Both
4. Neither
Lacosamide clinical application(s):
1. Partial seizure management
2. Pain syndromes
3. Both
4. Neither
Ion channels most directly associated with Lacosamide's mechanism of action:
1. Potassium
2. Calcium
3. Sodium