Medical Pharmacology Practice Questions: Anti-Seizures; Anti-Epileptic Drugs

Which one(s) of the following statement(s) concerning perampanel is/are correct?
1. Perampanel exhibits selective action at postsynaptic AMPA receptors.
2. Perampanel may be useful as an adjunct medication in managing partial seizures with or without secondary generalization (patients =>12 years of age)
3. Both
4. Neither
Relatively common adverse effects following perampanel administration:
1. Dizziness
2. Sleepiness
3. Headache
4. A & B
5. B & C
6. A, B & C
Perampanel exhibits a short half-life which prevents once-daily dosing.
1. True
2. False
Perampanel pharmacokinetics: choose (the) correct statement(s):
1. Perampanel aabsorption is rapid, allowing excellent bioavailability.
2. Perampanel is metabolized both by phase I (hepatic microsomal metabolizing system i.e. cytochrome P450 and phase II (glucuronidation)
3. Both
4. Neither
Perampanel levels are significantly affected by CYP3A cytochrome P450 isoform inducers, such as carbamazepine, phenytoin and oxcarbazepine.
1. True
2. False
Ezogabine (USA) a.k.a. retigabine: choose (the) correct statement(s):
1. Categorized as a potassium-channel "facilitator", representing a unique mechanism of action.
2. Absorption very sensitive to the presence of food which reduces absorption rate significantly.
3. Clinically useful as an adjunct treatment of adult partial-onset seizures.
4. & B
5. B & C
6. A & C
7. A, B & C
Frequently observed development of blue pigmentation (mainly on skin and lips) is associated with ezogabine.
1. True
2. False
Rufinamide:Adjuvant agent appropriate for seizure management in Lennox-Gastaut syndromes (patients = >4 years old)
1. True
2. False
Rufinamide administration does not appear to affect plasma levels of other drugs used for managing Linux-Gastaut syndrome (such as, topiramate, lamotrigine, valproic acid).
1. True
2. False
Rufinamide is extensively metabolized to inactive products, although the liver microsomal enzyme system is not apparently involve.
1. True
2. False