Medical Pharmacology Practice Questions: Anti-Seizures; Anti-Epileptic Drugs

Medical Pharmacology Chapter 19: Anti-Seizure; Anti-Epilepsy Drug Practice Questions

Approved in the United States for extended, long-term treatment of some seizure types:
1. Clorazepate
2. Clonazepam
3. Both
4. Neither
Likely useful for management of status epilepticus:
1. Lorazepam
2. Diazepam
3. Both
4. Neither
Receptor system most likely involved in mediation of benzodiazepine antiseizure effects:
1. Cholinergic
2. GABAergic
3. Adrenergic
4. Serotonergic
Which one(s) of the following statements about benzodiazepine pharmacokinetics is/are correct?
1. Generally well absorbed following oral administration..
2. Plasma concentrations peak usually within eight hours, following oral dose.
3. Following IV administration, CNS effects are rapidly prominent, given high drug lipid solubility
4. A & B
5. B & C
6. A & C
7. A, B & C
The principal metabolite of diazepam (N-desmethyl-diazepam) is an active metabolite.
1. True
2. False
Primary side effect associated with extended oral treatment with clonazepam:
1. Drowsiness
2. Lethargy
3. Both
4. Neither
Clinical anti-seizure utility associated with clonazepam:
1. Absence seizure treatment
2. Treatment of myoclonic seizures in children
3. Both
4. Neither
More likely used for treating status epilepticus due to its longer duration of action:
1. Diazepam
2. Lorazepam
Lorazepam, effective against absence seizure, has been identified as one of the most potent anti-seizure drugs developed.
1. True
2. False
Nitrazepam (not available in the United States) is effective for managing:
1. Myoclonic seizures
2. Infantile spasms
3. Both
4. Neither