Medical Pharmacology Practice Questions: Neuromuscular Blocking Drugs

Characteristic(s) of nondepolarizing neuromuscular blocking drugs:
1. Orally active
2. Lipid soluble
3. Both
4. Neither
Pharmacokinetic properties/properties of nondepolarizing neuromuscular blocking drugs:
1. Elimination of nondepolarizing neuromuscular blocking agents Exhibit zero-order kinetics, i.e. linear, concentration-independent
2. Readily cross cell membranes
3. Volume of distribution comparable to the blood volume
4. A & B
5. B & C
6. A & C
7. A, B & C
Neuromuscular blockade associated with nondepolarizing drugs is highly correlated with the elimination half-life.
1. True
2. False
Neuromuscular, nondepolarizing blockers which exhibit longer durations of action (greater than about half an hour) are most likely eliminated by:
1. Renal mechanisms
2. Hepatic mechanisms
3. No difference
Which one(s) of the following "intermediate-acting" steroid neuromuscular blocking drugs Exhibit elimination as a result of hepatic metabolism or biliary excretion.
1. Vecuronium
2. Roncuronium
3. Both
4. Neither
This intermediate-acting isoquinoline-type intermediate acting nondepolarizing drug exhibits Hofman elimination (spontaneous breakdown).
1. Pancuronium
2. Atracurium
3. Vecuronium
Tubocurarine (as well as other quaternary, charged, neuromuscular blocking drugs) show essentially no central effects after typical clinical doses.
1. True
2. False
This agent is most likely to ensure maintenance of the cardiovascular reflex, a condition preferable during anesthesia
1. Pancuronium
2. Tubocurarine
3. Vecuronium
This neuromuscular blocking agent exhibits a sufficient anti-vagal action such that tachycardia may ensue.
1. Vecuronium
2. Pancuronium
3. Tubocurarine
Cleared most slowly by the liver:
1. Pancuronium
2. Vecuronium
3. Roncuronium