Medical Pharmacology Practice Questions: Neuromuscular Blocking Drugs

The prototypical depolarizing-type neuromuscular blocking drug:
1. D-tubocurarine
2. Succinylcholine
Compared to atricurium, cisatracurium is:
1. More dependent on the liver for inactivation.
2. More likely to cause histamine release.
3. Both
4. Neither
Neuromuscular blockade reversal agent.
1. Sugammadex
2. Naloxone
3. Both
4. Neither
Cisatracurium is more clinically advantageous compared atracurium and as a result has replaced atracurium in practice.
1. True
2. False
Neuromuscular blockade due to depolarization induced by agents such as succinylcholine is initially described as a phase I block.
1. True
2. False
Succinylcholine, an example of a depolarizing neuromuscular blocker, exhibits longer duration compared to acetylcholine mainly due to which one(s) of the following?
1. Tighter binding to the acetylcholine receptor
2. Resistance to inactivation by acetylcholinesterase
Phase I blockade could be potentiated by which one(s) of the following?
1. Edrophonium
2. Donepezil
3. Both
4. Neither
Over time and with increasing succinylcholine concentrations, neuromuscular blockade may transition from a depolarizing, phase I block to a non-depolarizing phase II block.
1. True
2. False
Botulinum toxin which may be used to manage ocular blepharospasm as well as control other muscle spasms block neuromuscular transmission mainly through inhibition of acetylcholine release.
1. True
2. False
Muscle cell changes associated with prolonged depolarization include:
1. Reduced potassium
2. Increased sodium
3. Increased chloride
4. Increased calcium