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"(1) The high concentration of K+
ions inside the cell causes some of the K+ ions
to move (diffuse) out of the cell through the K+
ion channels."
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The inside of the
cell has a high K+
concentration compared to the outside
extracellular fluid. Thus, there is a significant
force, the K+
concentration gradient, acting to move K+
out of the cell.
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(2) However the negatively charged anions can
not exit the cell with the positive charged K+
ions because they are too large.
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(3) This creates a separation of charge across
the cell membrane. The inside of the membrane has
a lower potential (negative) and the outside has
a higher potential (positive)."
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courtesy of Robert H.
Parsons, Ph.D., Rensselaer Polytechnic Institute,
used with permission
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