Medical Pharmacology:
Sedative-Hypnotic Drug Practice
Questions
Click on the correct answer.
"Novel" benzodiazepine hypnotics are described as "Z compounds". Which one(s) of the following agents belonged to this group?
- Eszopiclone (Lunesta)
- Zaleplon (Sonata)
- Zopiclone
- Zolpidem (Ambien)
- A & C only
- B & C only
- A, B, C & D
"Z compounds" are usually now agents of choice for management of insomnia.
- True
- False
By contrast with benzodiazepines, physical dependence and tolerance during long-term administration of Z compounds may be expected.
- True
- False
Abrupt termination of zolpidem administration results in rebound insomnia.
- True
- False
Zaleplon (Sonata), a non-benzodiazepine agent, binds to CNS cholinergic receptors which mediate its pharmacological activity.
- True
- False
Zolpidem (Ambien) is a non-benzodiazepine sedative hypnotic agents that exerts its pharmacological effects through the GABA subtype A receptor.
- True
- False
Benzodiazepines affects notably the stages of sleep in human subjects. The non-benzodiazepine, zolpidem, by contrast, has little effect on the stages
- True
- False
Choose the correct statement(s) concerning zolpidem (Ambien):
- Zolpidem is subject to first pass hepatic metabolism
- Zolpidem oral bioavailability is about 10%.
- Both
- Neither
Eszopiclone may be used both for long-term insomnia treatment and sleep maintenance.
- True
- False
Eszopiclone exhibits rapid absorption following oral administration and a bioavailability of about 80%.
- True
- False
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