Medical Pharmacology Practice Questions: Sedative-Hypnotic Drugs

Which one(s) of the following statements concerning flumazenil (Romazicon) is/are correct?
1. Flumazenil binds with high affinity to the GABA subtype A receptor.
2. Flumazenil blocks behavioral but not electrophysiological effects of benzodiazepines.
3. Flumazenil is classified as a competitive antagonist.
4. A & B
5. A & C
6. A, B & C
Flumazenil route/routes of administration in clinical practice:
1. Intravenous
2. Oral
3. Both
4. Neither
Clinical use(s) of flumazenil:
1. Reversing benzazepine suspected overdose
2. Reversing sedation induced by benzodiazepine administration associated with diagnostic procedures or general anesthesia.
3. Both
4. Neither
Choose which one(s) of the following statements about flumazenil is/are correct?
1. Flumazenil is metabolized nearly completely by the liver.
2. Flumazenil metabolic products are biologically inactive.
3. Flumazenil administration is associated with substantial first-pass effects resulting in <25% of parent drug reaching systemic circulation.
4. All of the above statements are correct.
Flumazenil not only is effective in reversing benzodiazepine overdoses but is also helpful in reversing overdoses due to first-generation tricyclic antidepressants and barbiturates.
1. True
2. False
Administration of flumazenil to patients poisoned with tricyclic antidepressants will have no effect on the course of toxicity.
1. True
2. False
Ramelteon is a member of the latest benzodiazepine-sedative hypnotic class.
1. True
2. False
Ramelteon binds to which one(s) of the following receptor systems?
1. Nicotinic cholinergic
2. Muscarinic cholinergic
3. Adrenergic
4. Dopaminergic
5. Opiate receptors
6. None of the above
Choose the correct statement(s) concerning ramelteon clinical pharmacology:
1. Ramelteon should be administered about one half hour prior to bedtime.
2. Ramelteon is subject to substantial first-pass hepatic metabolism following oral administration resulting in low (<2%) bioavailability.
3. Both
4. Neither
Ramelteon Is helpful in managing transient but not chronic insomnia.
1. True
2. False