Medical Pharmacology Practice Questions: Sedative-Hynotics Drugs

Barbiturates have for most purposes been superseded by benzodiazepines, a safer drug class.
1. True
2. False
Which one of the following is more sensitive to the effect of barbiturates?
1. Peripheral nervous system
2. Central nervous system
Enhancement of neuronal inhibition by barbiturates occur at synapses using this neurotransmitter.
1. Acetylcholine
2. Norepinephrine
3. Lysine
4. Adenosine
5. GABA
Which one(s) of the following statements concerning barbiturates is/are correct?
1. Barbiturates promote binding of GABA to GABA receptors in a manner dependent on chloride ion, an effect shared by benzodiazepines.
2. Barbiturates enhanced benzodiazepine binding at the GABA receptor.
3. Both
4. Neither
Which one(s) of the following statements concerning barbiturates correct?
1. Barbiturates activate inhibitory GABA receptors.
2. Barbiturates inhibit excitatory AMPA receptors
3. Both
4. Neither
The range of CNS depression caused by barbiturate administration can extend from mild sedation to general anesthesia.
1. True
2. False
Concerning the development of tolerance to barbiturates:
1. Pharmacodynamic or functional tolerance to barbiturates may occur
2. Pharmacokinetic-based tolerance to barbiturates may occur
3. Both
4. Neither
Concerning pharmacokinetic and pharmacodynamic tolerance to barbiturates, choose which one(s) of the following statements is/are correct?
1. With chronic administration of slowly increasing doses, pharmacodynamic tolerance progressively develops over a period of weeks to months.
2. Typically pharmacokinetic tolerance peaks after a few days to a week.
3. Both
Neurogenic-based respiratory drive may be completely suppressed at a barbiturate dose three times higher than the normal hypnotic dose.
1. True
2. False
Prominent effects of barbiturate on the liver are associated with the cytochrome P450 microsomal drug-metabolizing system.
1. True
2. False