Medical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions

Concerning gastrointestinal mucosal defenses:
1. Mucosal defense depends in part on prostaglandins and nitric oxide, locally synthesized.
2. Damage to the gastric mucosa in absence of appropriate defense mechanisms can be mediated by gastric acid and pepsin
3. Both
4. Neither
Gastric acid-mediated mucosal damage may be managed or prevented by which one(s) of the following?
1. Reducing gastric pH (acidity)
2. Increasing mucosal defense systems
3. Both
4. Neither
This infectious agent is thought to play a central role in asset-peptic disease pathologies:
1. Spirochetes (especially Borrelia burgdorferi)
2. Helicobacter pylori
3. Acidobacterium capsulatum
Most effective drugs that reduce gastric acid secretion inhibit gastric H+, K+--ATPase (proton pump).
1. True
2. False
Typically, proton pump inhibitors are pro-drugs which undergo activation to a sulfenamide derivative.
1. True
2. False
Omeprazole (Prilosec and others) and esomeprazole (Nexium):
1. Esomeprazole is the S-isomer of omeprazole.
2. Omeprazole turns out to be about twice as potent as its S-isomer, esomeprazole.
3. True
4. False
Which one(s) of the following agents are classified as proton pump inhibitor(s)?
1. Lansoprazole (Prevacid)
2. Rabeprazole (AcipoHex)
3. Both
4. Neither
After administration, proton pump prodrugs reach stomach parietal cells and concentrate in acidic secretory canaliculi.
1. True
2. False
Proton pump inhibitors interact with H+, K+-ATPase (the proton pump) anyway characterized most importantly as:
1. Ionic bonding
2. Hydrogen bonding
3. Covalent bonding
4. Vanderwall's interactions
Reactivation of proton pumps inhibited by proton pump inhibitors:
1. Depend on slow diffusion of the drug away from the proton pump.
2. Hydrolysis of the drug catalyzed by water thus breaking the drug-enzyme bond.
3. Re-synthesis of new proton pumps, thus allowing a resumption of acid secretion.

Medical Pharmacology: Gastrointestinal Pharmacology Practice Questions