Duration of suppression of acid secretion following administration of proton pump inhibitors (e.g. omeprazole):

Proton pump inhibitors should been administered prior to the first meal of the day since the amount of proton pump ( H⁺, K⁺-ATPase) increases following fasting.

Typical dosing profile/profiles associated with proton pump inhibitors:

Associated following extended treatment with proton pump inhibitors:

Degradation of proton pump inhibitors following oral administration can occur due to exposure to acid in the gastric lumen. This effect may be limited by use of which one(s) of the following?

This/these proton pump inhibitors can be administered parenterally if the oral route of administration is not an option.

Concerning proton pump inhibitor metabolism:

Using once daily dosing of the proton pump inhibitor, this amount of time may be required to achieve 70% inhibition, level noted at equilibrium i.e. the steady-state.

Chronic renal disease including renal failure results in proton pump inhibitor drug accumulation following daily dosing.

Hepatic disease and possible effect on esomeprazole and lansoprazole clearance.