Medical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions

Among the proton pump inhibitors, this agent exhibits a relatively more rapid onset of gastric acid inhibition compared other oral preparations.
1. Lansoprazole
2. Dexlansoprazole
3. Rabeprazole
4. Omeprazole
This proton pump inhibitor is most likely associated with the shortest half-life.
1. Rabeprazole
2. Pantoprazole
3. Omeprazole
4. Lansoprazole
Proton pump inhibitors:
1. Weak bases
2. Weak acids
The bioavailability of proton pump inhibitors is enhanced by food and therefore should be administered following a meal.
1. True
2. False
Concerning inhibition of proton pumps by omeprazole and related agents:
1. These agents are effective inhibitors only when the proton pump is actively secreting acid.
2. A small fraction, about 10%, proton pumps secrete acid actively during fasting.
3. Both
4. Neither
Following proton pump discontinuation, as long as 3-4 days is required before normal acid secretion is reinitiated.
1. True
2. False
Proton pump inhibitors exhibit very limited renal clearance and exhibit first-pass as well as subsequent liver metabolism.
1. True
2. False
Due to the short half-life of a single injection of one of the intravenous formulations of pantoprazole and esomeprazole, maximal proton pump inhibition during the first 1-2 days of treatment requires either repeated bolus injections or continuous infusion.
1. True
2. False
Pharmacokinetic characteristic(s) of proton pump inhibitors:
1. Generally short serum half-life
2. Both concentrated in activated close to their intended site of action.
3. Relatively long duration of action.
4. A & B
5. B & C
6. A & C
7. A, B & C
Proton pump inhibitors represent the most efficacious drugs in the following therapeutic setting(s).
1. Reflux disease (GERD) effects on the esophagus including Barrett's esophagus and peptic stricture)
2. Extraesophageal presentations of reflex disease.
3. Both
4. Neither

Medical Pharmacology: Gastrointestinal Pharmacology Practice Questions