Medical Pharmacology: Gastrointestinal Pharmacology Practice Questions
Choose the correct answer for each question.
H2 receptor blockers suppress meal-induced acid secretion while maintaining normal basal gastric acid secretion.
True
False
H2
receptor antagonists are relatively nonspecific sense they block both H1 and H3-type histamine receptors.
True
False
Concerning H2 receptor blockers and liver metabolism:
H2 receptor blocker drug clearance is dependent on hepatic metabolism in the range of <10% to about 35%.
Liver disease by itself is sufficient to require dose adjustment in view of effects drug on clearance.
Both
Neither
H2 receptor blockers decrease acid secretion induced by histamine but acid secretion due to gastrin or cholinomimetic drugs is unaffected.
True
False
H2 receptor blockers:
Binding of histamine released from enterochromafin-like cells (ECL) in response to gastrin or vagus nerve stimulation to parietal cell issue receptors is inhibited by the H2 receptor antagonists.
Parietal cell stimulation by gastrin or the cholinergic neurotransmitter acetylcholine and associated histamine release is reduced by H2 receptor antagonists.
Both
Typically, side effects associated with H2 receptor blockers are considered typically minor and include:
Diarrhea
Headache
Both
Neither
Common side effects associated with H2 receptor antagonists administration include:
Fatigue
Constipation
Muscular pain
A & B
B & C
A & C
A, B & C
CNS side effects associated with H2 receptor antagonists administration are considered relatively common.
True
False
Concerning H2 receptor antagonists in the maternal setting:
These drugs cross the placenta and can be found in breast milk.
Cautious use describes use in pregnancy, although apparent major teratogenic risk has not been identified with these drugs.
Both
Neither
Nizatidine and famotidine exhibit limited effects on the liver microsomal cytochrome P450 system, thus limiting drug-drug interactions by this mechanism.
